We combine Xenopus developmental biology, single-cell and functional genomics, and genome engineering to understand how disease genes act during development and to build technologies for tissue repair, cancer therapy, and diagnosis.
Using Xenopus embryos to uncover the developmental functions of genes linked to human disease.
Single-cell analysis of cell fate and regeneration to develop technologies for repairing spine and joint injuries.
Using cancer-specific mutations and CRISPR genome editing to selectively eliminate cancer cells.
Image-based phenotyping of Xenopus models, and genome analysis for diagnosing disease and infection.